1550s, "poisoned;" 1570s, "drunk," past participle adjective from intoxicate (v.).
"to poison," mid-15c., from Medieval Latin intoxicatus, past participle of intoxicare "to poison," from Latin in- "in" (see in- (2)) + toxicare "to poison," from toxicum "poison" (see toxic). Meaning "make drunk" first recorded 1570s. Related: Intoxicated; intoxicating.
intoxicate in·tox·i·cate (ĭn-tŏk'sĭ-kāt')
v. in·tox·i·cat·ed, in·tox·i·cat·ing, in·tox·i·cates
To stupefy or excite, as by the action of a chemical substance such as alcohol.