1803, irregularly formed from system, used in medicine and biology for differentiation of meaning from systematic. Related: Systemically.
systemic sys·tem·ic (sĭ-stěm'ĭk)
adj.
Of or relating to a system.
Of, relating to, or affecting the entire body or an entire organism.
Relating to or affecting a particular body system, especially the nervous system.
Relating to systemic circulation.