c.1300, from Old French esplen, from Latin splen, from Greek splen, from PIE *splegh- (cf. Sanskrit plihan-, Avestan sperezan, Armenian p'aicaln, Latin lien, Old Church Slavonic slezena, Lithuanian bluznis, Old Prussian blusne, Old Irish selg "spleen"). Regarded in medieval physiology as the seat of morose feelings and bad temper. Hence figurative sense of "violent ill-temper" (1590s).
spleen (splēn)
n.
A large, highly vascular lymphoid organ, lying to the left of the stomach below the diaphragm and serving to store blood, disintegrate old blood cells, filter foreign substances from the blood, and to produce lymphocytes.
An organ in the lymphatic system, in the upper left part of the abdomen, that filters out harmful substances from the blood. The spleen also produces white blood cells, removes worn-out red blood cells from circulation, and maintains a reserve blood supply for the body.