late 14c., megrim, from Old French migraigne (13c.), from vulgar pronunciation of Late Latin hemicrania "pain in one side of the head, headache," from Greek hemikrania, from hemi- "half" + kranion "skull" (see cranium). The Middle English form was re-spelled 1777 on the French model. Related: Migrainous.
migraine mi·graine (mī'grān')
n.
A severe recurring headache, usually affecting only one side of the head, that is characterized by sharp pain and is often accompanied by nausea, vomiting, and visual disturbances. Also called hemicrania, megrim, sick headache.