mid-15c., from Medieval Latin incompatibilis, from in- "not, opposite of" (see in- (1)) + compatibilis (see compatible). Originally of benefices, "incapable of being held together;" sense of "mutually intolerant" is from 1590s. Related: Incompatibly.
incompatible in·com·pat·i·ble (ĭn'kəm-pāt'ə-bəl)
adj.
Incapable of associating or blending or of being associated or blended because of disharmony, incongruity, or antagonism.
Producing an undesirable effect when used in combination with a particular substance, as a medicine in combination with alcohol.
Not suitable for combination or administration because of immunological differences, as blood types.