1650s, from French granule or directly from Late Latin granulum "small grain," diminutive of Latin granum "grain" (see corn (n.1)).
granule gran·ule (grān'yōōl)
n.
A small grain or pellet; a particle.
A cellular or cytoplasmic particle, especially one that stains readily.
A very small pill, usually coated with gelatin or sugar.