"drop, globule," 1725, from a verb meaning "to make or mark with blobs" (early 15c.), perhaps related to bubble. The same word was used 16c. in a sense "bubble, blister."
Slang definitions & phrases for blob
blob
noun
A mistake (1900+ Students)
A mass of viscous matter; an amorphous portion; gob(1700s+)
A useless person; an oaf or wimp: she is such a blob after work/ blobs into video games
A very overweight person: Get that blob off my couch