1650s, abbreviated form of sister; in American English, applied generally to girls and young women (1859). It also was the familiar short form of Cecilie, Cicely, a common name for girls in the Middle English period.
suffix in Greek-derived nouns denoting action, process, state, condition, from Greek -sis, which is identical in meaning with Latin -entia, English -ing (1).
[a shortening of sister]